Türk Nöroşirürji Dergisi 2021 , Vol 31 , Num 3
DBS in Parkinson"s Disease: Mechanisms of Action
1Başkent Üniversitesi, Tıp Fakültesi, Adana Dr. Turgut Noyan Araştırma Merkezi Yüreğir Hastanesi, Beyin ve Sinir Cerrahisi AD, Adana, Türkiye
2Ondokuz Mayıs Üniversitesi, Tıp Fakültesi, Beyin ve Sinir Cerrahisi AD-Nöromodülasyon Merkezi, Samsun, Türkiye
3Maastricht Üniversitesi, Tıp Fakültesi, Beyin ve Sinir Cerrahisi-Nörobilim Anabilim Dalları, Maastricht, Hollanda
The most common movement disorder is Parkinson"s disease. Surgical treatment can be performed in cases where medical treatment is insufficient as in epilepsy, pain and some other conditions. Today, at a time when neuromodulation is gradually developing, deep brain stimulation is the leading surgical procedure for Parkinson"s disease. Many studies are being conducted to understand the mechanism of action of deep brain stimulation, and the effectiveness has been proven by various studies. The excitation and suppressive effects provided by the electrodes are processed by a complex neuronal network, and clinical results are obtained. In this review, the mechanisms of action of deep brain stimulation will be summarized. Anahtar Kelimeler : DBS, Mechanisms of action, Parkinson Disease