Türk Nöroşirürji Dergisi 2001 , Vol 11 , Num 1
Ağahan ÜNLÜ1, Gökalp SİLAV1, Ayşe KARATAŞ1, Bermans ISKANDAR2
1Ankara Üniversitesi Tıp Fakültesi Nöroşirürji Anabilimdalı, Ankara
2Wisconsin Üniversitesi Tıp Fakültesi Nöroşirürji Anabilimdalı, Madison, Wisconsin, ABD
So far, lot of studies have been done to improve or regain the neuronal disfunction and loss, caused by neurodegenerative diseases, stroke and trauma. Calcium which is a member of seconder messenger system involved in regulation of cellular events, has been the subject of some experiments. For this purpose, the effects of Verapamil-HCI, which is a voltage gated calcium channel blocker, on Central Nerve System regeneration was studied. The effects of 0.1 mg/kg dose on rats, whose dorsal column injured and grafted with a sciatic nerve graft at C2 level, was compared with placebo and sham surgery groups. As a result, there was regeneration in 75±16 cells and statistical analyse revealed significant difference between placebo (33.5±9.7, p=0,004) and sham surgery (33±4.2, p=0,002) groups. The regeneration at sciatic nerve lesion side is greater than the other side which the sciatic nerve was not cut. In Sham surgery group 19.3±5.4, in plasebo group 15.5±2.1, and in Verapamil group 20±11.1 cells were regenerated. It was suggested that Verapamil improves the regeneration of nerves. Anahtar Kelimeler : calcium channel blocker, dorsal root ganglion, nerve regeneration