Türk Nöroşirürji Dergisi 2014 , Vol 24 , Num 2
Computerized Tomography-Guided Stereotactic Biopsy of Intracranial Lesions: 15-Years Experience
S. Meltem CAN1, Osman N. TÜRKMENOĞLU1, Canan TANIK2, Ender UYSAL3, Barış ÖZÖNER1, Ayça KALDIRIMOĞLU1, A. Murat MÜSLÜMAN1, Adem YILMAZ1, Çiçek BAYINDIR4, Yunus AYDIN5
1Şişli Hamidiye Etfal Eğitim ve Araştırma Hastanesi, Beyin ve Sinir Cerrahisi Kliniği, İstanbul, Türkiye
2Şişli Hamidiye Etfal Eğitim ve Araştırma Hastanesi, Patoloji Kliniği, İstanbul, Türkiye
3Şişli Hamidiye Etfal Eğitim ve Araştırma Hastanesi, Radyoloji Kliniği, İstanbul, Türkiye
4İ. Ü. İstanbul Tıp Fakültesi, Nöropatoloji Bilim Dalı Em. Öğretim Üyesi, İstanbul, Türkiye
5Özel Memorial Hastanesi, Nöroşirürji Kliniği, Şişli, İstanbul, Türkiye
AIM: CT-guided stereotactic brain biopsy has been performed in our clinic since March 1998. In this prospective study, we examined the data of patients undergoing stereotactic biopsy and the results of the biopsies.

MATERIAL and METHODS: A total of 489 procedures were carried out in patients consisting of 176 (36.9%) females and 301 (63.1%) males, ages ranging from 3 to 81 (mean 50.18±16.92) years. The procedures were performed under general anesthesia in 17 children and one adult case and under local anesthesia in the others by using Leksell stereotactic frame system.

RESULTS: A conclusive histopathological diagnosis could not be made in 17(3.5%) of the 489 procedures. Of the others, 164 (33.5%) were high-grade gliomas, 96 (19.5%) were low-grade gliomas, 35 (7.2%) were malignant lymphomas, 35 (7.2%) were other types of brain tumors, 78 (16%) were metastases and 64 (13.1%) were nontumoral lesions. Complications occurred in ten cases: 3 tumoral bleeding, 2 hypertensive cerebral hematoma, 2 peroperative convulsions, 1 epidural hematoma, 1 myocardial infarction and 1 brain edema. The patients who developed myocardial infarction and hypertensive thalamic hematoma died. The mortality rate was 0.04% and the morbidity rate was 1.6% in 489 procedures.

CONCLUSION: Our data reveals that CT-guided stereotactic biopsy is a reliable and a safe procedure in cases with intracranial lesions when a histopathological diagnosis is required for the appropriate treatment. Anahtar Kelimeler : Brain tumors, Computerized tomography, Stereotactic biopsy