Türk Nöroşirürji Dergisi 2018 , Vol 28 , Num 1
Etiology of Cerebral Vasospasm
Mustafa Ömür KASIMCAN1,Burcu GÖKER1,Mustafa Kemal HAMAMCIOĞLU1,Talat KIRIŞ1
1İstinye Üniversitesi, Tıp Fakültesi, Beyin ve Sinir Cerrahisi Anabilim Dalı, İstanbul, Türkiye Subarachnoid hemorrhage (SAH) is a clinical condition in which blood in the cerebral vessels is distributed to the subarachnoid space due to trauma or vascular pathology. The quality of life is reduced in 69% of patients after SAH. Vasospasm and the associated cerebral ischemia are the main causes of post-SAH morbidity. Animal models and human studies on this issue support the notion that this problem is a factor-dependent physiopathological event. Various theories have been developed on spasmogens that cause vasospasm and various studies have been conducted with some still undergoing and some planned for the future. The studies have focused on nitric oxide, endothelin-1, calcium, hemoglobin and bilirubin degradation products. The purpose of this article was to review the main mechanisms that cause vasospasm in the light of current literature. Anahtar Kelimeler : Bilirubin, Calcium, Endothelin-1, Hemoglobin, Nitric oxide, Vasospasm