Türk Nöroşirürji Dergisi 2017 , Vol 27 , Num 2
Molecular Biology of Pituitary Adenomas
Burak ÇABUK1,Deniz SÜNNETÇİ AKKOYUNLU2,İhsan ANIK1,Savaş CEYLAN1
1Kocaeli Üniversitesi, Tıp Fakültesi, Nöroşirürji Anabilim Dalı ve Hipofiz Araştırma Merkezi, Kocaeli, Türkiye
2Kocaeli Üniversitesi, Tıp Fakültesi, Tıbbi Genetik Anabilim Dalı, Kocaeli, Türkiye
The tumorigenesis of pituitary adenomas is a complex multistep process in which many genetic and epigenetic changes, internal and external factors are involved. Oncogenes, tumor suppressor genes, cell cycle elements, genetic mutations, epigenetic modifications, microRNAs play role in this process. In this review, we will focus on the oncogenes, tumor suppressor genes, cell cycle elements and microRNAs which have role in tumorigenesis process Anahtar Kelimeler : Pituitary adenoma, microRNA, Tumorigenesis