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¹Eskişehir Osmangazi Üniversitesi, Tıp Fakültesi, Beyin ve Sinir Cerrahisi Anabilim Dalı, Eskişehir, Türkiye Bone formation in the human body is divided into intramembranous and endochondral ossification. The skull base bones are formed by enchondral ossification while the calvarium and facial bones are intramembranous ossification. The suture line is the center for intramembranous bone formation. In order to continue the growth of the skull, the middle section of this center must remain unossified and opposite edges of sutures must allow the formation of new bone by the osteoblasts. The tissues that interact with each other in the cranial suture complex to provide suture regulation are; dura mater, osteogenic edges of calvarial bone plates, mesenchymal tissue of cranial sac, and pericranium. Molecular regulation of suture growth and closure is achieved by interaction of transcription factors, cytokines, growth factor receptors and extracellular matrix molecules. Anahtar Kelimeler : Suture, Calvarium, Enchondral, Intramembranous, Ossification