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¹Sanko Üniversitesi, Tıp Fakültesi, Beyin ve Sinir Cerrahisi Anabilim Dalı, Gaziantep, Türkiye
²Sağlık Bilimleri Üniversitesi, Gülhane Eğitim ve Araştırma Hastanesi, Beyin ve Sinir Cerrahisi Anabilim Dalı, Ankara, Türkiye A large majority of the population suffers from low back pain at some point in their lifetime and some of sufferers become chronically disabled. Although low back pain is a multifactorial condition, there is a strong correlation with degeneration of the intervertebral disc. Intervertebral disc degeneration is characterized by an overall breakdown of extracellular matrix, combined with altered matrix synthesis and changes in cell number, cell phenotype and behaviour. While many of these features are evident during normal ageing, the changes are accelerated in degeneration and are associated with discogenic pain. However, the pathogenesis of disc degeneration and its role in low back pain have been poorly understood until recently. This article will review the physiopathological changes that occur during intervertebral disc degeneration at a molecular, cellular and tissue level. Anahtar Kelimeler : Annulus fibrosus, Intervertebral disc, Molecular biology, Nucleus pulposus, Physiopathology, Proteoglycan