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¹İstanbul Medeniyet Üniversitesi, Tıp Fakültesi, Nöroşirürji Anabilim Dalı, İstanbul Türkiye Trigeminal neuralgia (TN) is a sudden, short, stabbing, and recurrent pain within one or more divisions of the trigeminal nerve. Though multiple theories involving peripheral pathologies at the root (compression or traction), and dysfunctions of the brain stem, basal ganglion, and cortical pain modulatory mechanisms could play a role, the neurovascular theory is the most widely accepted theory. The diagnosis is basically made clinically; magnetic resonance imaging (MRI) is useful to rule out secondary causes and detect pathological changes in the affected root and neurovascular compression. Glycerol rhizotomy (GR) is percutaneous lesioning surgery generally used for the treatment of medically refractory trigeminal neuralgia (TN). Percutaneus retrogasserian glycerol injection is a simple, safe and effective treatment for trigeminal neuralgia that has been successfully used for more than 35 years. In this chapter we will review retrogasserian glycerol injection for trigeminal neuralgia. Anahtar Kelimeler : Trigeminal neuralgia, Glycerol injection, Retrogasserian ganglion