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¹Ankara Yıldırım Beyazıt Üniversitesi, Ankara Şehir Hastanesi, Ankara, Türkiye Traumatic brain injury is a serious health problem for the community. The high rate of traumatic brain injury in the active population increases the socioeconomic effect. The increasing rates of traumatic brain injury, which has no surgical indication, in developed countries increases the significance of the subject. Early intervention in this problem that may come up at any moment during daily work will increase the success of the subsequent stages. Secondary injuries after primary head trauma occur after metabolic changes and have negative effects on morbidity and mortality. Considering that the main purpose of medical treatment is to maintain the current situation, prevention of possible changes will be effective treatment. In this review article, we tried to provide information about the relevant metabolic processes. Anahtar Kelimeler : Trauma, Brain injury, Metabolism