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¹Adana Şehir Eğitim ve Araştırma Hastanesi, Beyin ve Sinir Cerrahisi Bölümü, Adana, Türkiye Traumatic brain injury (TBI) indicates an injury to the brain itself and can occur without any signs of external trauma. Pre-hospital management of patients with traumatic brain injury is critical and directly linked to clinical outcomes. In the period following local cerebral ischemia, the disruption of cerebrovascular autoregulation, and an injury associated with cerebral edema, the brain is at risk of secondary injury and focuses on limiting secondary brain damage while optimizing cerebral physiology. Secondary injury greatly affects the clinical outcome, and this damage can be minimized if appropriate resuscitative efforts are provided. Pre-hospital care providers are responsible for identifying both head and brain injuries, ensuring stabilization, and transporting these patients to an appropriate care center. In the emergency department, the necessary care includes making the definite diagnosis of the traumatic brain injury with or without extracranial lesions (especially with CT among the imaging methods) and triage to determine the appropriate structure for the following care. In addition to the prediction of TBI severity, investigation of other relevant lesions is of great importance in the emergency room. Anahtar Kelimeler : Emergency room, Pre-hospital care, Traumatic brain injury