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¹Mustafa Kemal Mahallesi, 2118. Cadde, No: 4B/102, Çankaya, Ankara Patients with traumatic brain injury should be monitored in the intensive care unit to avoid secondary injury. The main goal of monitoring is to maintain cerebral perfusion pressure. To reach this goal, detecting the oxygen status of brain tissue and the cerebral blood flow is crucial. Multimodal monitoring and some widely used methods provide direct knowledge about cerebral blood flow, the oxygen status of brain tissue, and cerebral perfusion pressure, or more importantly the changing patterns of these parameters. Multimodal monitoring allows cerebral perfusion pressure-driven treatments. It therefore provides better outcomes for patients with traumatic brain injury. Intracerebral pressure measurement, detection of brain tissue oxygen levels, microdialysis, transcranial Doppler, near infrared spectroscopy and continuous EEG are some of these useful methods. Anahtar Kelimeler : Brain oxygenization, Cerebral perfusion pressure, Intracranial pressure, Multimodal monitoring, Secondary damage, Traumatic brain injury