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¹Trakya Üniversitesi Tıp Fakültesi, Beyin ve Sinir Cerrahisi Anabilim Dalı, Edirne, Türkiye Osteoporosis is a metabolic disease that may lead to spinal fractures by decreasing bone quality. It has started to be seen more and more frequently with the increasing elderly population. Although most osteoporotic vertebral fractures show spontaneous healing, sometimes progressive collapse, kyphotic deformity and neural compression due to spinal canal or intervertebral foramen narrowing can be seen. Surgical treatment options are minimal invasive procedures such as vertebroplasty and instrumented stabilization in some cases. In most cases without deformity or neural compression, percutaneous cement support to the vertebral body (vertebroplasty/kyphoplasty) is sufficient, while in some cases decompression and instrumented stabilization are required. There are many factors to be considered during surgical indication determination and technique selection. Patient age, gender, comorbidities, weight, body structure, severity of osteoporosis, fracture localization, degree of collapse and angle, balance of the spine in sagittal and coronal planes, canal and foramen stenosis, pain severity, neurological deficit, the patient"s degree of activity and expectation from surgery, and the surgeon"s experience and available technical means are the main ones. The risk of failure of instrumental surgery is high due to reasons such as increased morbidity rates due to the advanced age of osteoporotic patients, mechanical insufficiency of the bone, and difficulty in fusion. Therefore, instrumentation should only be considered in patients with absolute indications. There are many measures that can be applied to prevent failure of the instrumentation system, and sometimes all of them need to be implemented. These measures are pharmacological treatment for osteoporosis, increasing the levels of fixation to distribute the load, using a sublaminar wire or hook, optimizing the screw application technique, changing the screw design, applying cement-supported screws, and supporting the anterior column. Fusion should be accelerated by good bone grafting. Despite all these measures, it should be kept in mind that spinal instrumentation in a patient with osteoporosis may fail and revision surgery may be required. Anahtar Kelimeler : Osteoporosis, Vertebral fracture, Instrumentation