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¹Koç Üniversitesi Hastanesi, Nöroşirürji Anabilim Dalı, İstanbul, Türkiye
²Koç Üniversitesi Tıp Fakültesi, Nöroşirürji Anabilim Dalı, İstanbul, Türkiye
³Koç Üniversitesi Hastanesi, Nöroşirurji Anabilim Dalı, Gamma Knife Merkezi, İstanbul, Türkiye Obsessive-compulsive disorder (OCD) is a serious neuropsychiatric disorder. Cognitive behavioral therapy and drug therapy with selective serotonin reuptake inhibitors are the recommended first-line therapies, while approximately 20% of patients are resistant to treatment as characterized by varying degrees of obsessive thoughts and/or compulsive behaviors. Deep brain stimulation (DBS) is a promising treatment for patients in this patient group. Various anatomical targets can be used, and meta-analyses have shown a response rate of approximately 60% to DBS treatment. Although DBS, as a reversible and controllable method, can provide such a high improvement in both functionality and quality of life in treatment-resistant cases, some patients cannot benefit from DBS sufficiently. As OCD is a very heterogeneous disease with many different symptoms, the ultimate goal is to find the optimal DBS target, maximize treatment efficacy, and minimize side effects through patient-specific adjustment of stimulation parameters. Anahtar Kelimeler : Deep brain stimulation, Neuromodulation, Obsessive-compulsive disorder