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¹Koç Üniversitesi Tıp Fakültesi, Patoloji Anabilim Dalı, İstanbul, Türkiye Meningiomas are the most common primary intracranial tumors in adults. The most defining feature in the clinical approach is the localization and histological grade. However, the uncertainty in the behavior of grade 2 meningiomas has led to debates that histomorphological grading does not fully meet the needs. Pioneering studies on the molecular features of meningiomas grouped tumors into two; meningiomas showing chromosome 22 loss and accompanying NF2 gene mutations, and meningiomas without these alterations. Detailed genomic, transcriptomic and methylomic studies stated that meningiomas could be classified according to their methylation profiles, and moreover, by combining all these features, a more complex distinction could be made, which could give more prognostic information. The final (fifth) edition of the World Health Organization Classification of Central Nervous System Tumors includes the molecular features of meningiomas, and the effects of some molecular features on tumor behavior, such as CDKN2A/B deletion and TERT promoter mutation are discussed in detail; moreover, it proposes to evaluate these alterations in some cases in routine practice. With more studies in the coming years, it may be possible to use an integrated diagnosis/grading system that incorporates molecular features with the histological criteria of meningiomas. Anahtar Kelimeler : Meningioma, Molecular features, Methylation, NF2, World Health Organization