Türk Nöroşirürji Dergisi
2022 , Vol 32 , Num 1
Treatment Strategy in Anaplastic Meningiomas
1Acıbadem Mehmet Ali Aydınlar Üniversitesi Tıp Fakültesi, Nöroşirürji Anabilim Dalı, İstanbul, Türkiye
Meningiomas are the most common primary intracranial tumors. Most of them are grade I benign tumors, but 2% of them are
grade III meningiomas with malignant characteristics. Most related studies are done by grouping them together with grade II
meningiomas as "high grade meningiomas" due to the low numbers. Data regarding their natural and history, clinical follow-up,
pathology, genetics and epigenetics are scarce, but have been increasing recently. MRI is the gold standard for their diagnosis and
treatment, but there is still no standard protocol for preoperative prediction of pathological grades. Surgical resection followed by
adjuvant radiotherapy is performed in their treatment as the standard protocol. Reoperation and radiotherapy should be preferred
for recurrent cases, but radiosurgery, Lu-177-DOTA-TATE, and chemotherapy can be advised for inoperable cases.
Anahtar Kelimeler :
Meningiomas, Anaplastic meningiomas, Malignant meningiomas, Grade III meningiomas