2Sivas Devlet Hastanesi, Beyin ve Sinir Cerrahisi Kliniği, Sivas
3Kulu Devlet Hastanesi, Beyin ve Sinir Cerrahisi Kliniği, Konya
4Gazi Üniversitesi Tıp Fakültesi, Beyin ve Sinir Cerrahisi Anabilim Dalı, Ankara
5Güven Hastanesi, Beyin ve Sinir Cerrahisi Kliniği, Ankara DOI : 10.5137/1019-5157.TND.3373 AIM: In this study, we aimed to investigate the relationship of peripheral blood parameters with grade prediction, IDH-1 mutation association, and progression-free survival in gliomas operated in our clinic and to contribute to the literature.
MATERIAL and METHODS: In our single-center retrospective study, demographic data of 91 glioma patients operated in our center between January 2019 and December 2021 were collected, and the relationship between IDH-1 mutations, progression-free survival and grades, and inflammatory blood parameters calculated from hemogram and biochemistry values in peripheral blood were associated using logistic regression and cox regression.
RESULTS: Increases in age, serum immune-inflammation index, neutrophil/lymphocyte ratio, and platelet/lymphocyte ratio were found in favor of high-grade glioma and decreases in these values were associated with IDH-1 mutation. Increases in albumin/ globulin ratio were in favor of low-grade glioma. Younger age, gross-total resection, and higher lymphocyte/monocyte ratio values were associated with longer progression-free survival.
CONCLUSION: Due to their cost-effectiveness and easy availability, peripheral blood parameters can be used as useful markers to predict glioma prognosis and progression.
Anahtar Kelimeler : İnflammation, Glioma, Neutrophil/lymphocyte ratio, Serum immune-inflammation index, Prognosis