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¹GATA Haydarpaşa Eğitim Hastanesi, Nöroşirürji Kliniği, İstanbul
²GATA Haydarpaşa Eğitim Hastanesi, Deniz ve Sualtı Kliniği, İstanbul
³GATA Haydarpaşa Eğitim Hastanesi, Radyoloji Kliniği, İstanbul
⁴GATA Haydarpaşa Eğitim Hastanesi, Patoloji Kliniği, İstanbul Both extrinsic and intrinsic factors affect the survival of neural tissue transplantation grafts. Grafts needs a time period for integration with the host after the transplantation. Cell loss of the graft is highest in this period since vascularization has not been completed yet. In our study, we investigated the effect of hyperbaric oxygen treatment (HBOT) on development rate and integration of the grafts. We used 30 Wistar albino rats. Rats were divided into three groups of 10 rats. In the first group only cavitation in the frontal was performed and then HBOT was given. In the second group, we transplanted fetal cortical tissue which was obtained from rat fetuses of 16-17 days of age following cavitation. In the third group we applied HBOT after the same transplantation procedure. HBOT was begun at the first hour after transplantation and was continued for 5 days. 100 % oxygen in 2 absolute atmosphere (ATA) pressure was applied to the rats for 90 minutes in each session, twice a day. Rats were sacrified at the end of the 7th day, after radiological evaluation. Analysis of histological and radiological findings showed that in addition to survival and development rate, the degree of integration of the grafts reached so optimum level in the third group. Anahtar Kelimeler : Fetal Cortex, Hyperbaric Oxygen, Rat, Transplantation