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¹KTÜ Tıp Fakültesi Patoloji, Anabilim Dalı, Trabzon
²KTÜ Tıp Fakültesi Nöroşirürji, Anabilim Dalı, Trabzon
³KTÜ Tıp Fakültesi Histoloji, Anabilim Dalı, Trabzon
⁴KTÜ Tıp Fakültesi İç Hastalıkları (Hematoloji-Onkoloji) Anabilim Dalı, Trabzon In recent years studies about flow cytometric DNA analysis of astrocytomas revealed the correlation between aneuploidy and turn or grade. Also, p53 and EGFr gene mutation rates were found to be high in these clinically aggressive tumors. Our study included 35 cases of astrocytomas diagnosed in KTU Pathology Department between 1994-1998. The cases are divided into two subgroups according to WHO-1993 classification as low and high grade tumors. Flow cytometric DNA analysis and p53- EGFr immunoreactivity are studied from paraffin embedded tissues. The relation between p53 pozitivityDNA aneuploidy and high grade tumors was statistically significant (p<0.05 and p<0.001, respectively). In contrast, S-indices and EGFr positivity were not statistically related to grade of the tumors. Mutant p53 protein and aneuploidy studies may be helpfull in grading especially in small biopsy specimens. Also, flow cytometric DNA analysis seems to be useful for predicting survival and therapy of the cases. Anahtar Kelimeler : Astrocytoma, flow cytometry, immunohistochemistry