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¹Selçuk Üniversitesi, Tıp Fakültesi, Tıbbi Genetik Bilim Dalı, Konya
²Selçuk Üniversitesi, Tıp Fakültesi, Nöroşirürji Anabilim Dalı, Konya The aim of this study was to identify the most frequent karyotypic abnormalities in meningiomas associated with histopathology and anatomic sites of tumor origin. Cytogenetic analysis of 28 cultured human meningiomas were performed by GTG-banding and evaluated according to ISCN 1995. It was revealed that 10(% 36) had normal karyotype, 8 (% 28.6) had monosomy 22 which was the sole abnormality and 10 (% 36) had structural abnormalities or loss of chromosomes l,4, 8, 10, 12, 15, 17, 19, 20, X and Y in addition to monosomy 22. Various chromosomal abnormalities were found in 18 (% 64) of these cases. Two cases exhibited complex translocations, in one patient various types of structural and numerical but non-clonal chromosomal abnormalities were found. Numerical alterations involving autosomal and sex chromosomes were detected in others. Karyotypic abnormalities were detected in six of meningothclial and three of fibroblastic and four of transtional, and all of psammomatous, angioblastic and anaplastic meningiomas. Correlation between tumors locations and their karyotypes were evaluated and it was seen that 12 of 18 cases whose tumors were located on the brain convexity had chromosomal abnormalities. Our results illustrated that, in addition to the frequent loss of chromosome 22, numerous other clonal karyotypic abnormalities exist in meningiomas, reflecting the heterogenity of biological and pathological findings. Anahtar Kelimeler : chromosomal abnormalies, cytogenetics, meningioma, monosomy 22