Türk Nöroşirürji Dergisi
2001 , Vol 11 , Num 2
INTRACRANIAL MALIGNANT MELANOMA- NEUROCUTANEOUS MELANOSIS: A REPORT OF TWO CASES
1S.S.Y.B. Şişli Etfal Eğitim ve Araştırma Hastanesi, Radyasyon Onkolojisi Kliniği, İstanbul2S.S.Y.B. Şişli Etfal Eğitim ve Araştırma Hastanesi, Patoloji Laboratuarı, İstanbul
3 S.S.Y.B. Bakırköy Ruh ve Sinir Hastalıkları Hastanesi 1. Nöroşirürji Kliniği, İstanbul
4İstanbul Üniversitesi Onkoloji Enstitüsü Tümor Patolojisi Bilim Dalı, İstanbul Neurocutaneous melanosis is a rare congenital syndrome characterised by large or numerous congenital pigmented nevi and excessive proliferation of melanincontaining cells in the leptomeninges. Adult cases are very rare. Therefore these two cases were presented and the literature was reviewed. A 20 year-old male patient had a intracranial mass in the left temporoparietal region. He had two congenital nevi on back and a small nevüs on the right thigh posterior. A 45 year-old male patient had a intracranial tumoral mass in the right frontal region and two congenital nevi on the left lumbal region and left food. Both of them were treated with surgical resection followed by external radiotherapy, combined biochemotherapy and hormonal therapy.
The incidence of intracranial malignant melanoma in neurocutaneous melanosis is remarkable. A t present there is no curative treatment. Radiotherapy is the most frequently used treatment for brain malignant melanomas. The combination of chemotherapy with hormonal therapy yields further improvement.
Anahtar Kelimeler : Biochemotherapy, hormonotherapy, intracranial malignant melanoma, neurocutanous melanosis, radiotherapy, surgery