Türk Nöroşirürji Dergisi
2013 , Vol 23 , Num 2
Craniopharyngioma
Akdeniz Üniversitesi, Tıp Fakültesi, Beyin ve Sinir Cerrahisi Anabilim Dalı, Antalya, Türkiye
Craniopharyngiomas are epithelial tumors that arise along the craniopharyngeal duct, and account for 5,6 to 13 % of intracranial tumors
in children. The first reported description of a craniopharyngioma was by the German pathologist, Friedrich Albert von Zenker in 1857.
These lesions remain among the most challenging pathologies for pediatric neurosurgeons because their location and degree of invasion
into surrounding neural and vascular structures, namely the hypothalamus, pituitary gland, optic apparatus and circle of Willus, make gross
total resection difficult, leading to a high rate of recurrence. Even after complete resection, these lesions have a propensity to recur, but the
rate of recurrence increases dramatically when resection is subtotal. Although gross total resection remains the therapeutic mainstay for
selected patients, a growing body of literature suggests that conservative surgical strategies, followed by adjuvant fractionated or targeted
radiotherapy, may achieve similar levels of tumor control while minimizing visual, neurologic and endocrine complications.
Anahtar Kelimeler :
Child, Craniopharyngioma, Treatment