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Erciyes Üniversitesi, Tıp Fakültesi, Nöroşirürji Anabilim Dalı, Kayseri, Türkiye The scientific and economic developments since the very beginning of the twentieth century has led to a prolonged human life span. The incidence of vascular disorders and cancer in those who live longer thanks to the advances in the field of health care is increasing. Management of central post-stroke pain, associated with vascular diseases seen in the aging population, is a very challenging situation. In patients that cannot be treated via conventional treatment methods, the need for neuromodulation will gradually increase. We, in this article, will mention a brief history and surgical techniques of motor cortex stimulation. Anahtar Kelimeler : Central poststroke pain, Neuromodulation, Fiber tracking, Functional magnetic resonance imaging