Türk Nöroşirürji Dergisi
2014 , Vol 24 , Num 2
Surgical Treatment in Cortical Dysplasia
İstanbul Üniversitesi, Cerrahpaşa Tıp Fakültesi, Beyin ve Sinir Cerrahisi Anabilim Dalı, İstanbul, Türkiye
Cortical dysplasia (CD) is among the most common diagnoses in patients with drug resistant epilepsy undergoing surgical treatment. CD
has been described in a current surgical series as the most common histopathological finding in the childhood population. Widely used
classification systems for CD are mostly based on histopathological characteristics; however, CD patients also show great discrepancies in the
mean of age of epilepsy onset, radiological findings, and location of the lesion.Preoperative evaluation of CD patients can be diff icult as none of the evaluation methods have the ability to determine the localization of the lesion precisely. Among these methods, the sensitivity of interictal scalp EEG is 48%; ictal scalp EEG 68%; magnetic resonance 66%; and fl uorodeoxyglucose–positron emission tomography (FDG-PET) 81%. Recent clinical series describe seizure control rates of more than 60% in these patients.
This article focuses on preoperative imaging modalities and surgical success in CD patients by reviewing diff erent CD types.
Anahtar Kelimeler : Cortical dysplasia, Cortical malformations, Epilepsy surgery