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¹Özel Erdem Hastanesi, Nöroloji Kliniği, İstanbul, Türkiye
²Acıbadem Üniversitesi, Tıp Fakültesi, Nöroşirürji Anabilim Dalı, İstanbul, Türkiye Deep brain stimulation is the most rapid expanding field in neurosurgery. Modern research on this subject began in the middle of the last century. Parkinson disease, essential tremor and dystonia are well established and evidence-based indications for DBS, and a number of other neurological and psychiatric indications are currently being investigated. There are some encouraging reports on a number of diff erent indications for DBS. The eff ectiveness, nondestructive and nonablative features, and the adaptability and reversibility of DBS have attracted the interest of clinicians lately. Evolving of DBS surgery has led to less use of ablative surgery. Despite the clinical success of DBS, its therapeutic mechanisms of action remains under debate. In this paper we discuss the historical evolution, the current views on the stimulation mechanisms, and the indications of DBS. Anahtar Kelimeler : Deep brain stimulation, Dystonia, Parkinsons disease, Tremor