Türk Nöroşirürji Dergisi 2016 , Vol 26 , Num - Ek
Molecular Biology of Schwannomas
Fatih BAYRAKLI1,2, Ramazan DOĞRUL1,2
1Marmara Üniversitesi, Tıp Fakültesi, Beyin ve Sinir Cerrahisi Anabilim Dalı, İstanbul, Türkiye
2Marmara Üniversitesi, Nörolojik Bilimler Enstitüsü, İstanbul, Türkiye
Schwannomas may occur spontaneously, or as a component of a familial tumor syndrome such as neurofibromatosis type 2 (NF2), schwannomatosis and Carney’s complex. Loss of function of merlin is the most important crossroad to the pathogenesis of these tumors, either by direct genetic change involving the NF2 gene on chromosome 22 or secondarily to merlin inactivation. Studying on the biology of these tumors helps to illuminate the genetic pathways leading to tumorigenesis and is crucial in identifying therapeutic targets.

In this review, we will shortly summarize the literature related with schwannoma molecular biology to provide an insight to the reader. Anahtar Kelimeler : Schwannoma, NF2 gene, Merlin, Molecular, Biology