Türk Nöroşirürji Dergisi 2016 , Vol 26 , Num 2
The Molecular Biology of the Blood-Brain Barrier in Brain Metastases
Murat ULUTAŞ1, Mehmet SEÇER2, Kadir ÇINAR1, Suat Erol ÇELİK3
1Sanko Üniversitesi, Tıp Fakültesi, Konukoğlu Hastanesi, Nöroşirürji Kliniği, Gaziantep, Türkiye
2Deva Hastanesi, Nöroşirürji Kliniği, Gaziantep, Türkiye
3Okmeydanı Eğitim ve Araştırma Hastanesi, Nöroşirürji Kliniği, İstanbul, Türkiye
In cancer patients, metastases of the malignant tumors to the brain constitute major morbidity and mortality. Several factors and mechanisms are involved in the development of brain metastases. A vast majority of brain metastases occur in lung and breast cancers and in malignant melanomas. For the metastatic cells to reach the brain parenchyma, they need to migrate through the capillary endothelial layer that constitutes blood-brain barrier (BBB). At the same time, BBB acts as a barrier to chemotherapeutic agents. The mechanisms underlying the interaction between the brain endothelial cells and cancer cells have not been clearly defined. Although the BBB acts as a protective barrier against cancer cells, at times it also plays an active role in their migration. In this manuscript, we review the mechanisms and signaling pathways that are involved in the transendothelial migration of metastatic cells. Anahtar Kelimeler : Blood-brain barrier, Metastasis, Endotel, Cancer, Cell, Transmigration, Molecular biology