Türk Nöroşirürji Dergisi 2017 , Vol 27 , Num 2
Role of Genetic Predisposition in Gliomagenesis
Yavuz OKTAY1,Cemaliye B. AKYERLİ2,Koray ÖZDUMAN3
1İzmir Uluslararası Biyotıp ve Genom Ensitüsü (iBG-izmir), İzmir, Türkiye
2Acıbadem Üniversitesi, Tıp Fakültesi, Tıbbi Biyoloji Anabilim Dalı, İstanbul, Türkiye
3Acıbadem Üniversitesi, Tıp Fakültesi, Nöroşirürji Anabilim Dalı, İstanbul, Türkiye
Frequent occurrence of cancer in certain families signifies familial inheritance of cancer. The classical knowledge indicated that such familial inheritance is rare in gliomas. Familial factors play a role in 5-10% of gliomas. However more recent molecular studies have shown that genetic factors may have a more significant role in glioma development. This review will summarize the current understanding in glioma inheritance. Concepts and mechanisms known in cancer predisposition will be discussed and specific findings on gliomas will be presented in this paper. Glioma inheritance is easily observed in cancer syndromes with mendelian inheritance that affect multiple organ systems. Observing the effect of polygenic inheritance is more complicated. With the development of targeted therapies that can specifically target inherited cases has created novel interest in these genetic changes. So, genetic inheritance plays an important role in gliomagesis. Anahtar Kelimeler : Glioma, Cancer predisposition genes, Glioma predisposition syndromes