Türk Nöroşirürji Dergisi 2017 , Vol 27 , Num 3
Epidemiology of Craniosynostosis
Ramazan PAŞAHAN1,Çağatay ÖNAL1
1İnönü Üniversitesi, Tıp Fakültesi, Beyin ve Sinir Cerrahisi Anabilim Dalı, Malatya, Türkiye Craniosynostosis can be defined as early fusion or absence of cranial sutures. The general prevelance is about 1/2500. It can be divided into two main groups as syndromic and nonsyndromic craniosynostosis. Syndromic ones make up nearly 15-20% of the whole group. The most common forms are the Apert and Crouzon Syndromes. Nonsyndromic craniosynostosis involves 80-85% of the whole pathology. The most frequent form is sagittal synostosis. The coronal synostosis group makes up 20-30% of the surgical cases. Besides genetic factors, some teratogens such as anticonvulsants, cytotoxic agents, and nitrosatable drugs are thought to be effective in the etiopathogenesis. For individuals where there is no definable aetiology, or those in whom a specific syndrome or chromosomal diagnosis cannot be identified, the recurrence risk for relatives and offsprings will be empiric and largely depend on the outcome of a careful clinical examination. Anahtar Kelimeler : Epidemiology, Genetics, Craniosynostosis, Nonsyndromic craniosynostosis, Syndromic craniosynostosis