Türk Nöroşirürji Dergisi 2019 , Vol 29 , Num 1
How Do Aneurysms Develop?
Orhan ALTAY1,Fatih ALAGÖZ1
1Sağlık Bilimleri Üniversitesi Ankara Numune Eğitim ve Araştırma Hastanesi, Beyin ve Sinir Cerrahisi Kliniği, Ankara, Türkiye An intracranial aneurysm is defined as ballooning of a cerebral vessel. It is most common between 30 and 60 years of age. More than 90% of aneurysms are below 10 mm and located in the anterior circulation. Aneurysms might be acquired or hereditary. An increase in the area as defined by the Young-Laplace law results in vessel dilatation. Hereditary factors play a major role in aneurysm development. Hypertension, smoking, alcohol intake and obesity are major acquired risk factors for aneurysm development. Cocaine use, head trauma and infections, aortic coarctation and arteriovenous malformation, connective tissue diseases, autosomal dominant kidney disease, neurofibromatosis type 1, Marfan syndrome, multiendocrine neoplasia type 1, pseudoxanthoma elasticum, hereditary hemorrhagic telengiectasia and Ehlers-Danlos synrome type 2 and 4 are other risk factors. Elastin, collagen type 1 A2, endothelial nitric oxide synthase, endothelin receptor A and cycline-dependant kinase inhibitor related genes are associated with aneurysm development. Mutations related to interleukin 6 are protective for aneurysm development. Relevant gene loci include 1p34-36, 2p14-15, 7q11, 11q25 and 19q13.1-13.3. Despite the presence of genetic factors in aneurysm development, the prognosis is mainly associated with the patient"s age and general neurological status at the time of presentation. Anahtar Kelimeler : Cerebral aneurysm, Risk factors, Genetic diseases, Aneurysm development