Türk Nöroşirürji Dergisi 2021 , Vol 31 , Num 3
DBS in Obsessive Compulsive Disorder Treatment
Yavuz SAMANCI1,Selçuk PEKER2
1Koç Üniversitesi Hastanesi, Nöroşirürji Anabilim Dalı, İstanbul, Türkiye
2Koç Üniversitesi Tıp Fakültesi, Nöroşirürji Anabilim Dalı, İstanbul, Türkiye
3Koç Üniversitesi Hastanesi, Nöroşirurji Anabilim Dalı, Gamma Knife Merkezi, İstanbul, Türkiye
Obsessive-compulsive disorder (OCD) is a serious neuropsychiatric disorder. Cognitive behavioral therapy and drug therapy with selective serotonin reuptake inhibitors are the recommended first-line therapies, while approximately 20% of patients are resistant to treatment as characterized by varying degrees of obsessive thoughts and/or compulsive behaviors. Deep brain stimulation (DBS) is a promising treatment for patients in this patient group. Various anatomical targets can be used, and meta-analyses have shown a response rate of approximately 60% to DBS treatment. Although DBS, as a reversible and controllable method, can provide such a high improvement in both functionality and quality of life in treatment-resistant cases, some patients cannot benefit from DBS sufficiently. As OCD is a very heterogeneous disease with many different symptoms, the ultimate goal is to find the optimal DBS target, maximize treatment efficacy, and minimize side effects through patient-specific adjustment of stimulation parameters. Anahtar Kelimeler : Deep brain stimulation, Neuromodulation, Obsessive-compulsive disorder