Türk Nöroşirürji Dergisi 2021 , Vol 31 , Num 3
Deep Brain Stimulation in Tourette's Syndrome
1Hacettepe Üniversitesi, Tıp Fakültesi, Beyin ve Sinir Cerrahisi Anabilim Dalı, Ankara, Türkiye Tourette"s syndrome is a child-onset neuro-psychiatric disorder characterized by sudden, rapid, repetitive, non-rhythmic, and stereotyped movements and/or vocalizations. It is frequently associated with comorbid psychiatric disorders. The treatment includes behavioral interventions and pharmacotherapy; ?2 adrenergic agonists, dopamine antagonists, dopamine depleters, benzodiazepines, antiepileptic drugs, and botulinum toxin injections are the mainstay of pharmacotherapy. Deep brain stimulation is considered in severe and refractory cases that do not respond to conventional approaches. The medial thalamus and GPi are especially promising among the many anatomic target locations that have been explored. The Yale Global Tic Severity Scale scores have improved around 50% on average in the select patients in whom GPi was stimulated. Nevertheless, the disorder is a heterogenous one and selection of the responsive patient population and decision making as regards targeting the various anatomical structures in different clinical pictures require further research. Anahtar Kelimeler : Tourette's syndrome, Deep brain stimulation, Neuro-psychiatric disorder