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¹Neuroplex Beyin, Sinir, Ağrı ve Epilepsi Hastalıkları ve Cerrahisi Merkezi, Ankara, Türkiye Epilepsy is a disease characterized by seizures, with a worldwide prevalence of approximately 0.5% to 1%. Approximately onethird of patients with epilepsy are in the drug-resistant group. Patients with partial seizures constitute the majority of drug-resistant epilepsies. Surgical resection or disconnection methods give very good results in well-selected patients. However, vagal nerve stimulation is a good option in patients who are not candidates for resective surgery. This system consists of a signal generator implanted under the clavicle and coiled electrodes placed around the left vagus nerve in the carotid sheath. In 1997, the vagal nerve stimulation method was approved by the FDA for patients over 12 years of age with partial onset and refractory to treatment. With the experience gained over the years and published results, it has been shown to be effective in children as well, and the age limit for approval was reduced to 4 by the FDA in 2017. In addition, VNS is also used as an adjunctive treatment method for seizure control in patients with generalized epilepsy. VNS, which is effective in patients with posttraumatic epilepsy and tuberous sclerosis, is one of the methods that comes to mind in the prevention of drop attacks in Lennox-Gastaut syndrome. Anahtar Kelimeler : Epilepsy, Drug-resistant epilepsy, Vagal nerve stimulation