Türk Nöroşirürji Dergisi 2023 , Vol 33 , Num 2
Genes Causing Pituitary Adenoma and Related Clinical Findings
Ceren ALAVANDA1,Özcan SÖNMEZ2,Bilgen Bilge GEÇKINLI1,Fatih BAYRAKLI2,Ahmet İlter GÜNEY1
1Marmara Üniversitesi, Tıp Fakültesi, Tıbbi Genetik Anabilim Dalı, İstanbul, Türkiye
2Marmara Üniversitesi, Tıp Fakültesi, Beyin ve Sinir Cerrahisi Anabilim Dalı, İstanbul, Türkiye
Pituitary adenomas are the third most common central nervous system tumors. They are a rare cause of mortality but can cause morbidity due to the mass effect or the hormones secreted. Although 95% of pituitary adenomas develop sporadically, it is possible to elucidate the underlying molecular etiology in 5%. The rate of detection of pathogenic variants increases in patients diagnosed at an early age, and those with a family history or an atypical adenoma. The most common genes associated with pituitary adenoma are AIP and MEN1 and the number of these genes has been increasing with recent studies. Genetic tests are important not only for the patient"s diagnosis but also for guidance regarding the follow-up of the patient and the family. Anahtar Kelimeler : AIP, Pituitary adenoma, MEN1, Genetics, Variant