Türk Nöroşirürji Dergisi 2002 , Vol 12 , Num 1
FIRST YEAR RADIOLOGICAL AND ENDOCRINOLOGICAL RESULTS OF PITUITARY ADENOMAS TREATED WITH GAMMA-KNIFE RADIOSURGERY
Türker KILIÇ1, Aşkın ŞEKER1, Selçuk PEKER1, Meriç ŞENGÖZ2, Oğuzhan DEYNELİ3, Sema AKALIN3, M. Necmettin PAMİR4
1Marmara Üniversitesi Tıp Fakültesi Nöroşirürji, Anabilim Dalı, İstanbul
2Marmara Üniversitesi Tıp Fakültesi Radyasyon Onkolojisi Anabilim Dalı, İstanbul
3Marmara Üniversitesi Tıp Fakültesi İç Hastalıkları Anabilim Dalı, İstanbul
4Marmara Üniversitesi Nörolojik Bilimler Enstitüsü, İstanbul
Objective: In the current neurosurgical practice, Gamma-Knife radiosurgery can be used an alternative treatment of residual or recurrent pituitary adenomas. In this study we present first year results of gamma-knife treated pituitary adenomas.

Methods: Thirty-nine pituitary adenoma patients with follow-ups of at least one year, among a total number of 82 cases treated between January 1997 - January 2000 in Gamma-Knife Unit in Marmara University are analysed in this study. All cases were followed up by MRI, visual field, and blood hormon levels at every 3 months. This report presents results of analysis of ongoing prospective clinical study.

Result: Except one case, tumor growth control achieved in all cases. At first year, endocrinologic control 66% in prolactinoma cases, 87% in GH adenomas and 50% in ACTH adenomas. Irreversible radiological changes or clinical neurological are not observed.

Conclusion: This initial assesment emphasizes that gamma-knife treatment can be an effective treatment modality for the control of anatomical growth and biochemical response in recurrent and residual pituitary adenomas, even in the short term period. Anahtar Kelimeler : Gamma-Knife, Radiosurgery, Pituitary Tumor