Türk Nöroşirürji Dergisi 2007 , Vol 17 , Num 1
Intracranial Hemangioblastomas: Clinical Analyses of 32 Patients
İstanbul Üniversitesi Tıp Fakültesi, Nöroşirürji AD. İstanbul OBJECTIVE: In this study microsurgically treated patients with intracranial hemangioblastoma and VHL syndrome during the period 1983-2005 were analysed retrospectively

METHODS: Patients' mean age was 40 years (19-67), 23 (%71) of them were male. 46 HBs were diagnosed in 32 patients and 9 (%28) patients had VHL syndrome. Five (%71) of the 7 multiple hemangioblastoma patients had VHL syndrome and 2 of them were incidental. 41 surgical interventions were performed to 32 patients (four to one patient, three to two patients, two to two patients). Subtotal resection, biopsy and ventriculoperitoneal shunting due to hydrocephalus were performed to 3 patients due to adhesion to the brain stem of the lesions.

RESULTS: 4 patients (%9) had minor surgical complications (closed CSF-leak and meningitis). After mean 60 months follow-up we observed regression or prevention of the progression of neurological symptoms. One patient died due to systemic complication of VHL syndrome.

CONCLUSION: After microsurgical total resection no recurrence was diagnosed in surgical area. Nowadays developed neuroradiological and genetic investigation tools facilitate follow up of asymptomatic VHL patients or immediate diagnosis of changes in presented or new developing lesions. The results are almost perfect by early diagnosed and microsurgically total resected patients. Anahtar Kelimeler : Hemangioblastoma, Surgical intervention, Von Hippel Lindau