Türk Nöroşirürji Dergisi 2008 , Vol 18 , Num 1
Expression of p53 Protein in the Clinical Behavior of Invasive Pituitary Adenomas
1Konya Numune Hastanesi, Nöroşirürji Kliniği, Konya
2Konya Eğitim ve Araştırma Hastanesi, Patoloji Laboratuvarı, Konya
AIM: p53 mutations are the commonest genetic changes in human cancers. Although pituitary adenomas (PAs) may be present up to 10% of population, the pathophysiology of these lesions is not well characterized. The aim was using by immunohistochemistry, understand to determine whether p53 accumulation is a correlations with invasiveness, recurrency, Ki-67 and hormonal function of adenomas.

MATERIAL and METHODS: 28 invasive PAs were examined. p53, Ki-67 and the hormone receptors were detected with immunohistochemistry. The adenomas were graded radiologically by Knosp`s classification.

RESULTS: P53 was detected in 9 patients. The p53 LI ranged from 0,01%-0,5%. Immunohistochemically, the distribution of p53 immunopositive Pas were 5/10 plurihormonal, 2/4 GH/PRL secreting and 2/5 PRL secreting adenoma. All of p53 positive adenomas expressed PRL. Two of the 7 nonfunctional adenomas were positive for p53. The LIs and presence of p53 were found more in grade 4 tumors than lower grade.

CONCLUSION: The p53 mutation was demonstrate no statistical correlation with hormonal type, invasiveness and Ki-67 LI of adenomas. However, mutations of p53 were identified in higher proportions of recurrent and more invasive adenomas and all of p53 positive adenomas expressed PRL. p53 mutation seem to be at least one mechanism by which pituitary adenoma progress. Anahtar Kelimeler : Pituitary adenoma, Invasive adenoma, p53, Ki-67, Immunohistochemistry