Türk Nöroşirürji Dergisi 2008 , Vol 18 , Num 2
Cerebellar Calcification in a Tuberous Sclerosis Patient: Case Report
Başkent Üniversitesi, Tıp Fakültesi, Nöroşirürji Anabilim Dalı, Ankara, Türkiye Tuberous sclerosis complex (TSC), first described by Desire-Magloire Bourneville, is an autosomal dominant neurocutaneus disease that involves the central nervous system, skin and internal organs. The classic clinical triad of tuberous sclerosis consists of mental retardation, epilepsy and adenoma sebaceum. The most common brain lesions in tuberous sclerosis are subependymal hamartomas, subependymal calcified nodules, cortical tubers, white matter hamartomas and giant cell astrocytoma. Cerebellar involvement, particularly cerebellar calcification, is however, extremely rare in tuberous sclerosis. In the literature, abnormal neuronal migration and organization have been considered in the etiopathogenesis of tuberous sclerosis. Similar to cerebral lesions, cerebellar calcification has also been argued to be the result of abnormal neuronal migration and organization. We discuss a case of tuberous sclerosis that presented with cerebellar calcification. Anahtar Kelimeler : Calcification, Cerebellum, Tuberous sclerosis