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Memorial Sağlık Grubu, Nöroşirürji Klinikleri, İstanbul, Türkiye Alien hand syndrome is an interesting and rare neurological finding characterized with one-sided involuntary movements and/or perception disorders of the hand, which develops due to an intracranial pathology. It is mostly seen in post-stroke, corticobasal degeneration, multiple sclerosis, Creutzfeldt Jakob’s disease or post-callosotomy patients. Alienation or the loss of proprioseptive awareness may seen on the affected hand. A forty-four years old male patient presented with estrangement and loss of control for two weeks on his left hand. He also had a weakness on the left side of his body for last two days. His neurological examination showed slight left hemiparesis, abnormal cerebellar findings, Romberg’s sign and involuntary movements on left hand. Cranial magnetic resonance imaging revealed a parafalxian extra-axial mass lesion in 6x5x5 cm size adjunct to bilateral premotor gyri and compression of the splenium of corpus callosum. Patient underwent surgical excision of the mass and all his pathologic neurological findings disappeared gradually at one week after surgery. Alien hand syndrome is a rare neurological phenomenon with unclear etiology and pathogenesis. Majority of the alien hand syndrome cases have been reported with frontal, parietal or corpus callosum lesions. Alien hand syndrome due to an intracranial mass is extremely rare. Anahtar Kelimeler : Alien hand syndrome, Corpus callosum, Meningioma, Parafalxian