Türk Nöroşirürji Dergisi 2003 , Vol 13 , Num 3
GLIOSARCOMA: CASE REPORT AND REVIEW OF THE LITERATURE
Abdulvahap GÖK1, Kemal BAKIR2, Cezmi ÜK1, İbrahim ERKUTLU1, Mustafa GÖK1
1Gaziantep Üniversitesi Tıp Fakültesi Nöroşirürji Kliniği, Gaziantep
2Gaziantep Üniversitesi Tıp Fakültesi Pataloji Kliniği, Gaziantep Objective: Gliosarcoma is an unusual variety of primary central nervous system tumors composed of glial and mesenchymal components. Gliosarcomas classified as a subgroup of glioblastomas show similiarity in relation with prognosis with glioblastoma. We studied two cases of gliosarcoma to discuss their histopathologic features and therapy.

Methods: Neurologic examination of these patierits revealed findings of increased intracranial pressure and neurologic deficits. Computerized tomography and magnetic resonance imaging demonstrated masses in the brain. After surgey radiotherapy was performed.

Findings: Despite surgical resection and radiotherapy tumor reccurrence was not prevented and both patients died after 8 and 10 months. In each neoplasm both glial and sarcomatous elements were found. Immunohistochemical examination and histopathological study confirmed the diagnosis of gliosarcoma.

Results: Gliosarcoma has an aggressive clinical behaviour with dismal prognosis. Surgical resection and radiotherapy is the treatment modality that was accepted. Anahtar Kelimeler : Gliosarcoma, histopathology, prognosis